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"While the delivery of nucleic acids remains a challenge, new carriers are introduced and tested continuously. Polymeric platforms have proven to be efficient in shielding nucleic acid cargos from nuclease degradation while promoting their delivery and intracellular release. Here, we venture beyond the delivery of conventional therapeutic nucleic acids and combine the stable cationic poly-(lactide-co-glycolide)-graft-polyethylenimine with functionalized NANPs."

Halman et al., Nanomedicine: Nanotechnology, Biology, and Medicine (2020)

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对核糖核酸的研究已经成为在现代生物和生物制药领域最突出的课题之一。核糖核酸在作为酶和自然支架以及基因表达调节体等方面的作用已被高度认可。我们实验室注重发展新颖且功能性的基于核糖核酸的纳米材料可以(1)与其他纳米材料或者细胞组织进行交流(2)对各种刺激进行及时反馈。从长远看来,我们的研究旨在改善目前治疗系统的操作方法并设计新颖的“智慧”的生物材料。

Nanoscale