​

1   Shapiro BA, Yingling Y, Bindewald E, Kasprzak W, Jaeger L, Severcan I, Geary C, Afonin KA. RNA nanoparticles and methods of use. US Patent No. US2010148085

​

2   Leontis NB, and Afonin KA. RNA complexes featuring paranemic binding, methods of their production and sensors and analytical methods involving same. US Patent No. US8129516B1

​

3   Shapiro BA, Afonin KA, Viard M, Bindewald E. Auto-recognizing therapeutic R/DNA chimeric nanoparticles (NP). U.S. Patent No. US9631192

​

4   Shapiro BA, Bindewald E, Afonin KA, Santhanam AN, Jaeger L. Therapeutic RNA switches compositions and methods of use. WO Patent No. WO2013075132A1

​

5   Shapiro BA, Afonin KA, Viard M. Triggering RNA interference with RNA-DNA and DNA-RNA nanoparticles. US Patent No. US20170274000A1

​

6   Shapiro BA, Yingling Y, Bindewald E, Kasprzak W, Jaeger L, Severcan I, Geary C, Afonin KA. RNA Nanoparticles and Nanotubes. US Patent No. US9732337B2

​

7   Shapiro BA, Afonin KA, Kireeva M, Kashlev M, Jaeger L, and Grabow WW. Co-transcriptional assembly of modified RNA nanoparticles. U.S. Patent No. US9719084B2

​

8   Shapiro BA, Afonin KA, Viard M, Martins AN. Multifunctional RNA nanoparticles and methods of use. U.S. Patent No. US10301621

​

9  Jones M, Afonin KA. Methods and compositions for biosensing. U.S. Patent No. US10627404B2

​

10  Aksimentiev A, Afonin KA, Wanunu M. Nucleic acid nanoparticles for analyte detection. US Patent No. 10,900,067.

​

11  Shapiro BA, Afonin KA, Bindewald E, Viard M, Kasprzak W, Dobrovolskaia M, Halman JR. Functionally-interdependent shape switching nucleic acid anticubes and other nanoparticles. U.S. Patent Application No. 62/480,899 filed April 3, 2017

​

12  Dobrovolskaia MA, Afonin KA, Hong E, Halman JR. Nucleic acid nanoparticles (NANPs) and methods of using the same for controlled immunomodulation, filed 2018

​

13  Afonin KA, Tabdanov E, Zhovmer A. Programmable Mechanobiological Platform. U.S. Patent Application No. 62/549,032 filed April 24, 2020

​

          14. Afonin KA, Dokholyan NV. Aptamer nanofibers and kill-switches and uses thereof. U.S. Patent application 62/942,884, filed July, 2022

​

​

​

​

1   NCI (Technology Transfer Center) executed a start-up-exclusive evaluation license with Sixfold Bioscience, Inc. for E-078-2016/0-      EIR-00, “Triggering of multiple functionalities using minimal RNA toeholds in RNA-based nanoparticles”. This license was negotiated by Jasmine Yang.

​

2   NCI (Technology Transfer Center) executed a start-up-exclusive evaluation license with Sixfold Bioscience, Inc. for E-765-2013/0-      EIR-00, “Multifunctional RNA Nanoparticles”. This license was negotiated by Jasmine Yang.