"While the delivery of nucleic acids remains a challenge, new carriers are introduced and tested continuously. Polymeric platforms have proven to be efficient in shielding nucleic acid cargos from nuclease degradation while promoting their delivery and intracellular release. Here, we venture beyond the delivery of conventional therapeutic nucleic acids and combine the stable cationic poly-(lactide-co-glycolide)-graft-polyethylenimine with functionalized NANPs."
Halman et al., Nanomedicine: Nanotechnology, Biology, and Medicine (2020)
The study of RNA has become one of the most prominent areas in modern biology and biomedicine. RNA is now appreciated to function as an enzyme, natural scaffold, and powerful regulator of gene expression. Our lab's mission is to develop novel functional RNA-based nanomaterials that can either (i) communicate with each other or with cellular machinery or (ii) be readily responsive to various stimuli. In the long term, our research aims at improving the operation of current therapeutic systems and engineering novel “smart” biomaterials.